Leadership

With a focus on capacity building, this training program has placed key emphasis on strong leadership, with the belief that this will build up investigators in the field of HIV-TB research at BJGMC. A leadership team that represents both JHU and BJGMC meets monthly to review trainee progress and program development. A training advisory committee meets quarterly to review the technical aspects of the program, and is composed of leaders in TB research in India and the United States. The final component of the leadership structure is a group of committed mentors at Johns Hopkins who will be available to form lasting relationship with the trainees and others at BJGMC as they build up their research portfolios.

Leadership Team

Andrea DeLuca

Project Director

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Leadership Team

Andrea DeLuca

Project Director

Ms. DeLuca is a Research Associate faculty member in the Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health.  She is based part-time in India.  Ms. DeLuca has nine years of research experience, particularly in multi-center TB research.  She initially coordinated a USAID-funded project in TB clinics in South Africa, and moved on to be part of the Consortium to Respond Effectively to the AIDS TB Epidemic (CREATE).  CREATE was a portfolio of population level studies aiming to lower the incidence TB in areas of high HIV prevalence, and Ms. DeLuca's work focused on community engagement and advocacy for policy change.  In 2009 Ms. DeLuca began working for the Pneumonia Etiology Research for Child Health (PERCH) project as the senior-coordinator of a 7-site hospital-based case-control study.  As part of the BJGMC-JHU Fogarty program, she will focus on institution capacity building and monitoring and evaluation.  Ms. DeLuca also works on the C-TRIUMPH cohort study based at BJGMC.

Dr. Amita Gupta

Scientific Director

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Leadership Team

Dr. Amita Gupta

Scientific Director

Amita Gupta, MD, MHS

Dr. Gupta is Deputy Director of the Johns Hopkins (JH) Center for Clinical Global Health Education (CCGHE), and Associate Professor of Infectious Diseases at the JH School of Medicine, with a joint appointment in International Health at the JH Bloomberg School of Public Health.

Board certified by the American Board of Internal Medicine in infectious diseases, Dr. Gupta specializes in international public health, clinical research, and education in infectious diseases, HIV/AIDS, and tuberculosis (TB). Since 2002, her work has been focused primarily on India, where she leads several Indo-JHU research collaborations, including the C-TRIUMPH and RePORT consortium for tuberculosis (TB) research funded by the US National Institutes of Health (NIH) and the government of India. Dr. Gupta is also Co-principal Investigator of the NIH-funded Baltimore-Washington-India (BWI) HIV and Infectious Diseases Clinical Trials Unit (CTU), and she is an active clinical investigator in multi-country HIV/TB trials conducted by the AIDS Clinical Trials Group (ACTG) and the International Maternal Pediatric Adolescent AIDS Trials Network (IMPAACT). Additionally, she has been awarded research grants from the NIH, CDC, and several philanthropic foundations to investigate TB in children and pregnant women, malnutrition, infection and inflammation, HIV treatment outcomes, and antibiotic resistance.

Dr. Gupta is an author of more than 90 peer-reviewed research publications and 7 book chapters, primarily on prevention and treatment of HIV, TB, and other infectious diseases, predominantly in low- and middle-income settings. She has also mentored more than 30 junior scientists in India and the US to run research studies and submit their own scientific findings to peer-reviewed publications.
From 2000–2002, Dr. Gupta worked for the US Centers for Disease Control and Prevention (CDC), where she was engaged in global public health projects in the US, Guatemala, Vietnam, and Micronesia.

Dr. Gupta received an undergraduate degree from MIT, a Doctor of Medicine from Harvard Medical School, and a Master of Health Sciences in clinical investigation from JH Bloomberg School of Public Health. She completed her internal medicine training at San Francisco General Hospital-University of California, San Francisco, followed by a post-doctoral fellowships with the Epidemic Intelligence Service at the US Centers for Disease Control and Prevention and at the JHU School of Medicine.

Dr. Dileep Kadam

BJGMC Program Coordinator

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Leadership Team

Dr. Dileep Kadam

BJGMC Program Coordinator

Dr. Kadam is the Head of the Department of Medicine at BJGMC and has been a long-standing research collaborator and leader of the BJGMC-JHU HIV research partnership. Dr. Kadam is Director of the National AIDS Control Organization (NACO) ART Center, one of the largest government HIV care providers in India. Dr. Kadam has mentored and taught students at BJGMC for 30 years and is a co-investigator on a number of ACTG studies. He will be the local institutional leader and coordinator for this training program.  His experience and leadership at BJGMC for many years will ensure that the best candidates are recruited and selected for the program and that they are provided the institutional support required to be successful in their research careers.

Dr. Nikhil Gupte

BJGMC Data Management and Statistical Core Director

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Leadership Team

Dr. Nikhil Gupte

BJGMC Data Management and Statistical Core Director

Dr. Gupte is a Research Associate faculty member in the Johns Hopkins School of Medicine. He is based full-time in India and is the Data Management Director and Deputy Director of the BJGMC CTU.  Through the support of the Hopkins Fogarty AITRP, Dr. Gupte received his PhD in Biostatistics from the Johns Hopkins Bloomberg School of Public Health, under the guidance of Dr. Ron Brookmeyer.  After receiving his PhD, he returned to India as a leader of the BJGMC-JHU research partnership.  He has over 10 years of experience in public health research in developing countries. His research is focused on clinical, behavioral and lab research related to HIV/AIDS and TB prevention in India.  He is also the lead statistician on a phase II randomized, open-label trial of rifapentine in place of rifampicin for intensive phase treatment of smear-positive pulmonary tuberculosis currently ongoing in South Africa.  In addition, Dr. Gupte is a recognized leader in Biostatistics education in India. He has developed and taught biostatistics courses at MIMER Medical College Talegaon and the Department of Statistics, University of Pune.  He has also developed and taught a number of NIH-supported Biostatistics training courses in India, including the first on-line course in Biostatistics in India. Dr. Gupte will establish a Data Management and Biostatistical Core Facility at BJGMC for the trainees, where he will teach courses for the Core Research Competencies I and II Seminar Series, as well as provide data management and statistical support for the trainees.

Dr. Robert Bollinger

Principal Investigator

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Leadership Team

Dr. Robert Bollinger

Principal Investigator

Dr. Bollinger is a Professor of Medicine, Public Health and Nursing at Johns Hopkins, where he established and has led the Hopkins India Fogarty AITRP Program since 1992.  The Fogarty India AITRP has trained 119 Indian scientists at Hopkins in degree programs, the Summer Institute and laboratory research.  The Fogarty India AITRP has also trained many hundreds of Indian scientists over the years through multiple in-country training workshops and conferences. Dr. Bollinger has worked collaboratively in India since 1979.  He established and has directed many Indo-US, NIH-supported HIV research collaborations in Pune, including PAVE, HIVNET, HPTN, HVTN, Acute HIV Study (R01), the SWEN Clinical Trial, and the BJGMC CTU.  In 2010, he helped to transition Dr. Amita Gupta to become the new Principal Investigator for the BJGMC CTU. Since that time, he has remained a Co-investigator on the CTU and has continued to mentor students and faculty from Hopkins and from India working together on a wide range of research projects in Pune.  In 2005, he established the Hopkins Center for Clinical Global Health Education, which has been a leader in the use of ICT and distance learning technology to support training in resource-limited settings around the world.  He has leveraged the unique capacity at the CCGHE to support many ongoing training programs for the faculty and students at BJGMC and elsewhere in India.  With the support of the Fogarty AITRP, Dr. Bollinger and colleagues conducted the only randomized trial demonstrating the effectiveness of distance learning training platforms vs. standard class-room based training in India.  In addition to demonstrating that the distance learning format for teaching courses in Biostatistics and Human Research Ethics was equivalent to the more expensive face-to-face training, these on-line courses are available for free in an open-course on-line and CD-rom based format and have been completed by >1000 trainees from around the world.

Faculty Mentors

Dr. Bill Bishai

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Faculty Mentor

Dr. Bill Bishai

Dr. Bishai is Professor of Medicine at Johns Hopkins with extensive research experience in several areas of mycobacterial research, including drug and drug target discovery, animal models, molecular pathogenesis, host-pathogen interactions, and molecular genetics.  For 18 years his work has focused on tuberculosis (TB).  In particular, he has worked on the roles of Mycobacterium tuberculosis (M.tb.) sigma factors, the generation of transposon mutants, knock-in and knock-down strategies, and the use of mutants in understanding the mechanism of action of existing and novel anti-TB compounds and drug regimens.  Dr. Bishai will be available to mentor BJGMC trainees interested in research related to TB pathogenesis and disease diagnosis and chemotherapy.

Dr. David Dowdy

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Faculty Mentor

Dr. David Dowdy

Dr. Dowdy is Assistant Professor in the Department of Epidemiology of the Johns Hopkins Bloomberg School of Public Health. He has conducted evaluations of TB diagnostic tests in the United States and Brazil.  Using traditional epidemiological and statistical techniques, he has conducted cohort studies of people living with HIV/AIDS in the United States and South Africa, ICU survivors, and TB suspects in Brazil and Uganda.  As a health economist, he has evaluated the costs and cost-effectiveness of numerous TB diagnostic tests (sputum smear microscopy, culture, serology, hypothetical point-of-care tests, and nucleic acid amplification) in seven countries (the United States, Brazil, India, China, South Africa, Uganda, and Kenya).  Dr. Dowdy is best known as a mathematical modeler. He has evaluated the medium-term epidemiological and economic impact of improved TB diagnostic tests: both locally and globally, in hypothetical and real populations. Dr. Dowdy will be available to mentor trainees from BJGMC who are interested in research related to HIV/TB coinfection, mathematical modeling, health economics, or translational epidemiology.

Dr. Eric Nuermberger

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Faculty Mentor

Dr. Eric Nuermberger

Dr. Nuermberger is Associate Professor of Medicine and International Health at Johns Hopkins, where he has been engaged in the development of new drugs and the repurposing of existing agents for the treatment of TB for over a decade. His laboratory’s work in in vitro and animal models has informed the clinical development of virtually all drugs currently in clinical trials for TB (e.g., moxifloxacin, rifapentine, PA-824, OPC-67683, TMC207 and PNU-100480). He has been a leader of the TB Transformative Science Group of the AIDS Clinical Trials Group (ACTG) and the Core Science Group of the TB Trials Consortium. He has mentored more than 10 graduate students and post-doctoral fellows who have worked on projects related to the development of improved in vitro and animal models for TB drug development applications, the evaluation of new drug candidates in pre-clinical models, pharmacodynamically based optimization of drug dosing and the kinetics of the emergence of drug resistance. Dr. Nuermberger will be available to mentor trainees from BJGMC who are interested in research related to the chemotherapy of TB.

Dr. Gyanu Lamichhane

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Faculty Mentor

Dr. Gyanu Lamichhane

Dr. Lamichhane is an Assistant Professor in the Johns Hopkins School of Medicine and an investigator in the Hopkins Center for TB Reseaerch. His primary research interest has been focused on the identification of genes/proteins required for growth of M. tuberculosis (Mtb). Dr. Lamichhane has received numerous research awards, including the Paul Ehrlich Research Award and the W. Leigh Thompson Excellence in Research Award. Dr. Lamichhane is a faculty mentor on the Hopkins Post-doctoral Infectious Diseases Fellowship T32 grant and has personally mentored 10 trainees. Dr. Lamichhane will be available to mentor BJGMC trainees with interest in research related to basic growth assays and fundamental basis of drug resistance of M. tuberculosis.

Dr. Jonathan Golub

Associate Professor of Medicine

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Faculty Mentor

Dr. Jonathan Golub

Associate Professor of Medicine

Dr. Golub is Associate Professor of Medicine at Johns Hopkins and an leading investigator in the Hopkins Center for TB Research, where his research focuses on the epidemiology, detection and prevention of TB in developing countries. He developed a Johns Hopkins based ICOHRTA training program for Brazilian researchers and over the past 7 years, over 70 trainees have attended the program and continue to be mentored. For 3 years, this program was extended through a Fogarty supplement to include trainees researching HIV-related malignancies from Brazil and South Africa. In addition, he has led three large cluster randomized trials in Rio de Janeiro, Brazil investigating preventive treatment and case finding strategies for TB in Brazil and currently is PI of an R01 clinical trial assessing smoking cessation among HIV-infected patients in South Africa. Also, in Brazil, South Africa and other countries, he is leading several studies investigating the impact of social determinants on TB disease, including diabetes and tobacco exposure. Dr. Golub leads a Fogarty training program for Brazil and South Africa and participates in other training grants as faculty mentor. He has personally mentored 28 trainees. Dr. Golub will be available to mentor BJMC trainees with research interest in HIV-TB epidemiology.

Dr. Kelly Dooley

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Faculty Mentor

Dr. Kelly Dooley

Dr. Dooley is an Assistant Professor at the Johns Hopkins School of Medicine. In addition to her MD and Clinical Fellowships in both Infectious Diseases and Clinical Pharmacology, Dr. Dooley has a Ph.D in Clinical Investigation. Her research has focused on evaluation of new tuberculosis treatment regimens, with particular interest in the pharmacology of TB and HIV drug interactions.  She is a recognized leader in HIV-TB research, having served on the Tuberculosis Trials Consortium Pharmacokinetic and Pharmacodynamic Studies Working Group, the AIDS Clinical Trials Group (ACTG) Tuberculosis Transformative Science Group (TB TSG), the International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT) Tuberculosis Scientific Group and Chaired the Drug Evaluation Subcommittee of RESIST-TB Working Group.  Dr. Dooley is a faculty mentor for the Hopkins Clinical Pharmacology T32 Training Grant and has mentored 6 research trainees over the past 3 years. Dr. Dooley is available to mentor BJGMC trainees with research interest in the pharmacology of drugs used to treat TB among those co-infected with HIV.

Dr. Nikki Parrish

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Faculty Mentor

Dr. Nikki Parrish

Dr. Parrish is Assistant Professor in the Department of Pathology and Director of Medical Mycobacteriology, at the Johns Hopkins School of Medicine. Her research focus has been on the biochemistry and genetics of Mycobacterium and she has more than 18 years of experience in the field of tuberculosis drug research and clinical diagnostic development. She also has been involved in numerous clinical studies including evaluation of new technologies, clinical trials with subsequent FDA approval of new diagnostic tests, and development of novel methods for routine clinical use. Over the years, she has trained many graduate students, laboratorians, medical technologists, research fellows and residents. Dr. Parrish has also been a technical consultant for the BJGMC CTU in Pune, to assist in the expansion of laboratory capacity for the isolation and characterization of TB. Dr. Parrish will be available to mentor trainees from BJGMC trainees with interest in laboratory research of tuberculosis.

Dr. Petros Karakousis

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Faculty Mentor

Dr. Petros Karakousis

Dr. Karakousis is Associate Professor at the Johns Hopkins School of Medicine and a lead investigator in the Hopkins Center for TB Research, where his research has focused on the development of several in vitro and in vivo models of TB latency and studies of the regulatory and metabolic networks required for M. tuberculosis growth restriction and antibiotic tolerance. Recently, he has developed novel assays to determine drug resistance from archived isolates of patients with MDR-TB. He has collaborated in the past on several studies with Dr. Bollinger, leading to scientific publications. He is faculty mentor for a number of other training grants, including the Division of ID T32 Postdoctoral program and has been an excellent mentor to 16 trainees over the past 10 years at Hopkins. Dr. Karakousis will be available to mentor BJGMC trainees who are interested in research related to the molecular mechanisms of TB latency and the development of rapid molecular diagnostic methods for detection of TB and drug resistance.

Dr. Sanjay Jain

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Faculty Mentor

Dr. Sanjay Jain

Dr. Jain is an Associate Professor in the Johns Hopkins School of Medicine, with a joint appointment in the Department of International Health. He is Director of the Hopkins Center for Infection and Inflammation Imaging Research. His primary research interests have been TB pathogenesis with a focus on translational research on molecular imaging, diagnostics and CNS TB. He has a dedicated and fully equipped biosafety level 2 and 3 spaces, small animal imaging equipment (CT, PET, SPECT/CT), bio-safety cells. He is a recipient of the NIH Directors New Innovator Award and has been a faculty mentor for 4 training grants (Pediatric ID Post-Doctoral Fellowship NIH T32, Pediatric Departmental NIH T32, Department of Pediatrics K-12 program and the Adult ID Post-Doctoral Fellowship NIH T32). He has personally mentored 24 trainees in his laboratory since 2005. Dr. Jain will be available to mentor BJGMC trainees interested in laboratory-related translational research in HIV-TB co-infection.

Dr. Shyam Biswal

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Faculty Mentor

Dr. Shyam Biswal

Dr. Biswal is a Professor in the Johns Hopkins Bloomberg School of Public Health where his research has focused on the pathogenesis of respiratory diseases. His laboratory has done the seminal translational research that provided the link between defect in Nrf2 with progression of COPD lungs and cigarette smoke induced emphysema in mouse models. His laboratory was first in reporting the overarching induction of multitudes of antioxidant genes and detoxification pathways by nrf2 activation and its ability to activate antibacterial defenses and phagocytosis in macrophages from COPD patients and mouse models. Dr. Biswal is also PI of a Fogarty Training Grant supporting research capacity strengthening with multiple institutions in and near Pune, India, focused on the relationship between respiratory diseases and indoor air pollution. Dr. Biswal’s area of research is of great interest to BJGMC, since up to 70% of HIV-TB patients in Pune have exposure to indoor air pollution through use of biomass fuel cooking. Dr. Biswal has mentored more than 25 fellows in last 10 years as a mentor for individual NRSA and also the NIEHS and the NHLBI institutional training grant. Dr. Biswal is available to mentor BJGMC trainees with who are interested in research related to innate immune response, exposure to indoor air pollution or cigarette smoke and TB.

Dr. Vidya Mave

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Faculty Mentor

Dr. Vidya Mave

Dr. Mave is CRS Leader and Director for the BJGMC CTU in Pune, where she coordinates all of the clinical research activities for the BJGMC-JHU partnership, including the ACTG and IMPAACT trials. She is also on the faculty of the Johns Hopkins Department of Medicine. Prior to returning to India, she was an Assistant Professor of Infectious Diseases at Tulane University. Her research interests include the epidemiology of latent TB infection among pregnant women, the role of vitamin D levels in pediatric TB infection and studies of the patterns of TB drug resistance in Pune. Over the past 2 years, she has mentored 8 pre-doctoral and postdoctoral trainees from Hopkins, who have come to Pune for research training and experience. Dr. Mave will be available to mentor BJGMC trainees with interest in HIV-TB epidemiology and clinical research.

Dr. Yuka Manabe

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Faculty Mentor

Dr. Yuka Manabe

Dr. Manabe is an Associate Professor of Medicine at Johns Hopkins where she began her faculty career studying the molecular and immunopathogenis of TB. Her interest in immune reconstitution inflammatory syndrome brought her to the Infectious Diseases Institute at Makerere University in Uganda in 2007 where she began clinical research in TB-HIV co-infection and more recently have begun some translational research in TB immunopathogenesis. From 2008-2012, she was also Head of Research at IDI and mentored many young PhD and Masters students.  Dr. Manabe will be available to mentor BJGMC trainees with interest in TB epidemiology, TB clinical trials, and implementation science in the area of TB-HIV integration of care.

Training Advisory Committee

Dr. Ajay Chandanwale

TAC Chair

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Training Advisory Committee

Dr. Ajay Chandanwale

TAC Chair

Dr. Chandanwale is the Dean of BJMC in Pune, where he is responsible for all of the operational and administrative issues of the medical school and associated
teaching hospital (Sassoon General Hospital). He is also Co-PI of the BJMC CTU. He will serve as the Chair of the TAC and will help selection of candidates for TB-HIV research training. He will also be responsible for supervision and guidance of BJMC’s institutional commitment to the Fogarty training program and for ensuring that the HIV-TB research capacity built by this program is ultimately transitioned to full institutional leadership, ownership and sustainability.

Dr. Camilla Rodrigues

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Training Advisory Committee

Dr. Camilla Rodrigues

Dr. Rodrigues is a Senior Consultant Clinical Microbiologist at the Hinduja Hospital in Mumbai. She directs the CAP-accredited Microbiology Laboratory at the hospital, which includes an internationally recognized TB laboratory. Dr. Rodrigues’s laboratory receives >14,000 samples/year for TB culture and has established state-of-the-art capacity for detection and genetic characterization of MDR- and XDR-TB. Dr. Rodriques is a member of the Regional Advisory Committee on MDR-TB for WHO (SEARO) and a member of the Government of India Ministry of Health Task Force for Antibiotic Resistance. Dr. Rodriques has more than 170 peer-reviewed publications, primarily related to TB and has mentored many students in TB research.

Dr. Richard Chaisson

TAC Co-Chair

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Training Advisory Committee

Dr. Richard Chaisson

TAC Co-Chair

The TAC Co-Chair is Richard Chaisson, MD, Professor of Medicine, Epidemiology and International Health. Dr. Chaisson has conducted HIV research since 1985 and
has extensive experience in clinical cohorts, opportunistic infections and TB and HIV. He is former Director of the Johns Hopkins AIDS Service, co-founder, with Richard Moore, of the Johns Hopkins HIV Clinic Cohort (JHHCC), founder and director of the JHU Center for TB Research and Principal Investigator of the Consortium to Respond Effectively to the AIDS-TB Epidemic (CREATE), a Gates Foundation-funded research collaboration conducting large-scale cluster-randomized trials to evaluate TB/HIV control strategies. He is also PI of a Fogarty ICOHRTA training grant in AIDS and TB in Brazil, and co-PI of an ICOHRTA for AIDS and TB in South Africa. He is PI of 3 NIH research grants studying HIV and TB in Africa and was recently appointed Chair of the TB Transformative Science Group of the ACTG. Dr. Chaisson is also the PI and Administrative Core Director of the Hopkins Center for AIDS Research (CFAR).

Dr. Soumya Swaminathan

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Training Advisory Committee

Dr. Soumya Swaminathan

Dr. Swaminathan is Director of the National Institute for Research in Tuberculosis (formerly the Tuberculosis Research Centre) in Chennai. She is an internationally recognized TB expert. She has been on the Editorial Board of Clinical Infectious Diseases, Chair of the HIV Section for the International Union Against Tuberculosis and Lung Diseases, Coordinator for Research of WHO/TDR, Geneva, Member of the Childhood TB subgroup for the DOTS Expansion Working Group of the Stop TB partnership. She is also a member of the TB Scientific Committee of the NIH IMPAACT Network.

Dr. Susan Dorman

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Training Advisory Committee

Dr. Susan Dorman

Dr. Dorman is Associate Professor of Medicine at Johns Hopkins School of Medicine and a lead researcher in the Hopkins Center for TB Research. She leads a number of international TB research studies, including the NIH-funded Clinical Diagnostic Research Consortium (CDRC). She is on the Editorial Board of the Journal of Clinical Microbiology and is on the US HHS Advisory Council for the Elimination of Tuberculosis. The focus of her research has been the development and evaluation of new diagnostic tests and strategies, as well as new treatment strategies, for TB. Her work spans the inter-related processes of diagnostic development, analytical accuracy assessments, clinical accuracy assessments, evaluation and demonstration studies, implementation research, and economic research.